Depending on what time you arrive in Milan, you will want to first head to see the Last Supper, located inside Santa Maria della Grazie. This is Leonardo di Vinci’s original fresco painting. It is one of the most famous paintings in the world, and because of the style of painting and its age, environmental factors such as humidity have destroyed much of the original painting, so they only allow a certain number of visitors in the room to see it each day.
I would advise you buy your tickets online in advance, or you will NOT get in, or if you are lucky enough to get in, you will spend an eternity in a line or queue. We did not buy our tickets in advance and because of that the closest we got to viewing this famous piece of art was a replica behind bars on the outside of Santa Maria della Grazie. We were still able to tour the chapel, which is lovely, but please learn from our mistake and buy your tickets in advance. You can do so here.